Travel light:State shedding for efficient operator migration

Operator migration is a crucial concept to adapt event processing systems to dynamic changes. When the placement of a stateful operator changes, the operator state must be migrated to the new host. However, operator state size and time constraints can make it impossible to migrate the operator without severe Quality of Service (QoS) degradation. As a relief, we propose to perform state shedding in such a situation. The core idea of state shedding is to partition the operator state, assign a utility to each partial state, and use the utility and size of each partial state to identify the most useful partial states that can be migrated in a given time frame. Thus, state shedding can maintain a substantially higher QoS with a lower impact on query results than state-of-the-art solutions targeting consistent state at the old and new host. In this paper, we define this novel approach and in a simulation environment evaluate state shedding in migration scenarios with pattern-matching queries

Fuzzy logic-based approximate event notification in sparse MANETs

Mobile Ad-Hoc Networks (MANETs) are an important communication infrastructure to support emergency and rescue operations. To address the frequent disconnections and network partitions that might occur, we have developed a distributed event notification service (DENS) for sparse MANETs. In most event notification solutions, subscriptions are formed with crisp values or crisp value ranges. However, in emergency and rescue operations subscribers may not always have time to give crisp values or crisp value ranges. Moreover, subscriber's interests in queries have gradual nature and subjective measure that calls for computing by words. Therefore, we design and implement a simple fuzzy concept based subscription language allowing more expressive subscriptions and more sophisticated event-filtering. It is built on two new ideas: using features as multi-attribute indexes of the subscription and predicate patterns for processing subscriptions with arbitrary Boolean operators. However, requiring more computational efforts, fuzzy logic introduces performance penalties in the whole network. The proposed services have been evaluated for run-time, space and scalability efficiency. The proposed design framework is extensible to the user- and application-semantics and configurable to the dynamics in data that publish/subscribe paradigm imposes at runtime

Using routing information to optimize synchronization of replicated event notification mediators in sparse MANETs

Mobile Ad-Hoc Networks maintain information about reachable nodes in the routing table. In many application scenarios, human groups play an important role. This is visible at the network level as independent network partitions which are for some time stable before their members change through merging or partitioning. We use the information from stable routing tables to optimize the synchronization of Mediators in our Distributed Event Notification System. In a stable partition each node has the same information, thus a single Mediator can efficiently coordinate the synchronization, while all other Mediators just receive updates. We show in our experiments that just a few seconds are needed until routing tables stabilize and all nodes have a common view of the partition. We present a heuristic which each individual node uses to determine the proper time to synchronize. Furthermore, we show how exceptions, like disappearing coordinating Mediators and unexpected messages, can be efficiently handled

Towards Scalable and Affordable Content Distribution Services

peer reviewe

fMR-adaptation indicates selectivity to audiovisual content congruency in distributed clusters in human superior temporal cortex

<p>Abstract</p> <p>Background</p> <p>Efficient multisensory integration is of vital importance for adequate interaction with the environment. In addition to basic binding cues like temporal and spatial coherence, meaningful multisensory information is also bound together by content-based associations. Many functional Magnetic Resonance Imaging (fMRI) studies propose the (posterior) superior temporal cortex (STC) as the key structure for integrating meaningful multisensory information. However, a still unanswered question is how superior temporal cortex encodes content-based associations, especially in light of inconsistent results from studies comparing brain activation to semantically matching (congruent) versus nonmatching (incongruent) multisensory inputs. Here, we used fMR-adaptation (fMR-A) in order to circumvent potential problems with standard fMRI approaches, including spatial averaging and amplitude saturation confounds. We presented repetitions of audiovisual stimuli (letter-speech sound pairs) and manipulated the associative relation between the auditory and visual inputs (congruent/incongruent pairs). We predicted that if multisensory neuronal populations exist in STC and encode audiovisual content relatedness, adaptation should be affected by the manipulated audiovisual relation.</p> <p>Results</p> <p>The results revealed an occipital-temporal network that adapted independently of the audiovisual relation. Interestingly, several smaller clusters distributed over superior temporal cortex within that network, adapted stronger to congruent than to incongruent audiovisual repetitions, indicating sensitivity to content congruency.</p> <p>Conclusions</p> <p>These results suggest that the revealed clusters contain multisensory neuronal populations that encode content relatedness by selectively responding to congruent audiovisual inputs, since unisensory neuronal populations are assumed to be insensitive to the audiovisual relation. These findings extend our previously revealed mechanism for the integration of letters and speech sounds and demonstrate that fMR-A is sensitive to multisensory congruency effects that may not be revealed in BOLD amplitude per se.</p

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection